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Nutritional deficiency due to excessive carbohydrate restriction: While reducing carbs can be beneficial for weight loss, cutting them too drastically can lead to fatigue, nutrient deficiencies, and a slowdown in metabolism
Shift from restrictive dietary approaches to focusing on what the body needs to be healthy both physically, mentally and for overall well-being
Conversely, the ubiquitin ligase E3 HUWE1/MULE, which acts as a negative regulator of ferroptosis, regulates iron metabolism by targeting transferrin receptor 1 and counteracts abnormal iron accumulation, thereby alleviating acute liver injury caused by hepatic ischemia-reperfusion (I/R) [34]
10.1016/j.molcel.2012.09.025 212 ShabkhizanR.HaiatyS.MoslehianM
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