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In addition, bortezomib treatment can also lead to mitochondrial damage, causing mitochondria to produce a large amount of reactive oxygen species (ROS), thereby damaging mitochondrial function and producing cytotoxic effects [29]

Low iron is one of the most common reasons for deferral

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Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops