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Ghannoum M, Lalibert M, Nolin TD, MacTier R, Lavergne V, Hoffman RS, et al

doi: 10.1155/2018/1489132

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Blunted JNK activation mediates hepatoprotection in LKO mice Considering the pattern of attenuated expression of genes related to cell death and injury combined with preserved mitochondrial function in the LKO mice, we next examined the JNK signaling pathway, a central mediator of APAP-induced mitochondrial dysfunction and necrotic cell death