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Sean Wharton, leader of the Wharton Medical Clinic for Weight and Diabetes Management in Ontario, Canada

Strengths: Only semaglutide product Health Canada-approved for weight management Highest dose (2.4 mg) delivers the strongest average weight loss about 15% body weight over 68 weeks in STEP 1 [4] SELECT trial demonstrated 20% reduction in major adverse cardiovascular events [2] Five-step titration schedule helps manage GI side effects Limitations: Insurance coverage for weight management is inconsistent across provinces and private plans Higher dose means higher rates of nausea, vomiting and diarrhea during titration Out-of-pocket cost is roughly $380$500 per month [5] Read our Wegovy guide for titration tips and coverage advice

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Semaglutide has a terminal half-life of approximately 1 week (about 7 days or 168 hours), according to FDA prescribing information

Over the course of 12 months, a 56-year-old patient achieved an incredible 60-pound weight loss through a comprehensive Medical Weight Loss program