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Upon inhalation of an e-cigarette, the vapour containing nicotine and flavouring agents enters the airways, altering the activity of such xenobiotic metabolising enzymes by both upregulation and inhibition, causing both an increase and decrease in drug metabolism

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The sitcom, that also made household names of Jennifer Aniston, David Schwimmer, Matt Le Blanc and Matthew Perry, ran for 10 seasons until 2004