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It appears that tobacco exposure increases the likelihood of having oral HPV-16 infection, and although we do not yet know why, we suspect that the virus may not be cleared from the body as easily in people who use tobacco, said study author Gypsyamber DSouza, PhD, MPH, MS, an associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, in a statement